Topical Ankaferd Blood Stopper Administration to Bleeding Gastrointestinal Carcinomas Decreases Tumor Vascularization
Turhan et al.
Am J Gastroenterol
. 2009 Nov;104(11):2874-7.
A 78-year-old female patient who presented with rectal bleeding was evaluated by flexible rectosigmoidoscopy, which
revealed a 3.5 × 4 cm semi-pedunculated
hemorrhagic, polypoid mass in the rectum. Multiple biopsy specimens were obtained, followed by a topical administration of 3 ml ABS to achieve hemostasis. Aft er a histopathological diagnosis of
adenocarcinoma, low anterior resection was performed 9 days later.
A 42-year-old male patient who was admitted to our hospital with complaints of epigastric pain, decreased appetite, nausea, and vomiting had an ulcerative vegetated lesion arising from the pylorus
and extending into the bulbus on upper endoscopy. Multiple biopsy specimens were collected from the lesion after which 5 ml of ABS was administered. A histopathological diagnosis of gastric
adenocarcinoma was confi rmed followed by total gastric resection 16 days later.
About the Role
Th e results from these two cases,
although presumptuous, demonstrated
meaningful decreases in MVD measurements in the tissue exposed to ABS, compared with MVDs from biopsy specimens before ABD administration and from deeper (unexposed) neoplastic tissue. Th ese fi ndings suggest the presence of a secondary, more sustained, mechanism of hemostasis, besides the initial protein network.