ABS (Ankaferd Hemostat) has emerged as a novel haemostatic agent of plant origin. Its ability to interact with entire proteins including cell surface receptors and/or blood proteins plus tissue proteins revealed novel functions of ABS to biologic systems especially tumor associated transcription factors. Thus, in our study, we aimed to investigate the effects of ABS on lymphoid neoplastic cells in vitro. We showed that Ankaferd treated B-CLL cells (at doses 0.5, 1 and 2 µg/mL) ceased to inflate and more than 50% of tumor cells were died compared to 0.1 and 0.25 µg/mL doses. Additionally, transformation of B-CLL cells to the blastic aggressive lymphoid forms was prevented by addition of Ankaferd to culture medium. The results have given the clues of anti-neoplastic effects at higher doses (>0.5 µg/mL) and induction of cellular differentiation at lower doses (<0.5 µg/mL) and proposed future advances in treatment of neoplastic bleedings.